Disease - EDK - BIG Data Center

Disease name	Thyroid Cancer
Classfication	Cancer
Related Enzyme(s)
EFO	EFO:0002892
DOID	1781
OMIM	-
NCI	NCI:C8054 NCI:C4815
Definition	An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.

Gene symbol	Disease	Enzyme	Editing Sites	Editing Type	miRBase	PMID	Description
hsa-miR-200b	Breast Cancer Gastric Cancer Head and Neck Cancer Endometrial Cancer Thyroid Cancer	ADAR1;ADAR2	1	A-to-I	MI0000342	28411194	miR-200b editing shows correlations with TP53 in breast cancers. High editing level in miR-200b is associated with worse patient survival.
hsa-miR-99a	Thyroid Cancer Head and Neck Cancer Breast Cancer	ADAR1;ADAR3	1	A-to-I	MI0000101	28411194	miR-99a editing shows correlations with TP53, HRAS, MAP3K1, PIK3CA in breast cancer, head and neck cancer, thyroid cancer.
has-mir-6503	Thyroid Cancer	ADAR1	1	A-to-G	NA		hsa-miR-6503 are edited within the seed region in a subset of CLL samples but not in B cells. These editing events alter miRNA target specificity and likely affect the pathogenesis of the disease.